NMN, or Nicotinamide Mononucleotide, is a pioneering derivative of vitamin B3 and represents an exciting front in molecular biology and health research.
This compound has caught the attention of science because of its potential in anti-aging and health-promoting properties.
To understand the importance of NMN, it is important to delve deeper into the molecular biology underlying this compound and its relationship with NAD+ (Nicotinamide Adenine Dinucleotide), Read more about NAD+ an essential molecule that plays a major role in the body's biological processes.
At the molecular level, NMN is part of a group of molecules known as nucleotides, which are the building blocks of RNA and DNA. Although NMN is part of the nucleotide group, it does not function as a direct building block for DNA and RNA.
Structurally, NMN consists of three main chemical groups: a phosphate group, a ribose sugar, and a nicotinamide base. NMN is converted directly to nicotinamide adenine dinucleotide (NAD+), thereby increasing levels of NAD+, which is why NMN is often referred to as an NAD+ booster.
NMN, NAD+, and cellular health
NAD+ is a critical cofactor found in all living cells and is essential for energy production, DNA repair, and regulation of gene expression. It is involved in the transfer of electrons in redox reactions, which are central to cellular metabolism. With age, people experience a natural decrease in NAD+ levels, which is linked to aging processes and the development of several diseases.
NMN acts as a direct precursor to NAD+ and has been shown to increase levels of NAD+ when taken as a supplement. This has potentially significant implications for delaying aging and improving metabolic health, cardiovascular disease, neurodegenerative disorders, and more. If you want to learn more about what NAD+ is and its importance, we recommend reading our article "What is NAD+?".
Research findings and potential health benefits
- Energy and Vitality: Increased NAD+ levels through NMN supplementation are linked to improved mitochondrial function, which are the powerhouses of our cells. This can lead to increased energy and endurance.
- DNA repair: By supporting DNA repair mechanisms, NMN can help maintain cellular and genetic integrity, which is essential for preventing cancer and age-related decline.
- Metabolic health: NMN has been shown to improve insulin sensitivity and blood sugar control, which are key factors in fighting metabolic syndrome and diabetes.
- Neuroprotection: There are also indications that NMN may have protective effects on the brain, by promoting neuronal health and function, which may be relevant in the treatment and prevention of neurodegenerative diseases.
- Epigenetic age: Several users have reported a reduction in epigenetic (biological) age after using NMN. You can easily measure your biological age with our age test that we have in collaboration with epiAge.
How to use NMN?
When it comes to optimal use of NMN to maximize the health benefits, we recommend a daily dosage of between 500 mg and 1000 mg of. To ensure the best possible absorption, it is ideal to take NMN on an empty stomach, preferably in the morning. An effective method is to place the powder directly under the tongue, where it can be absorbed quickly into the bloodstream. Alternatively, NMN can be mixed with a nutritious meal, such as yoghurt for breakfast.
This flexibility in administration makes it easy to integrate NMN into your daily routine, backed by research that points to significant health benefits, including improved energy levels and potential anti-aging effects. By following these guidelines, you can take a proactive step towards strengthening your body's health and well-being.
Safety profile and ongoing studies
This scientific breakthrough reflects our dedication to providing effective solutions to maintain vitality and well-being. The research behind NMN strengthens our understanding of how we can optimize the body's health in a way that has never been possible before, and we look forward to the positive effects this will have for people all over the world.
In any case, I would like to point out that although the studies at NMN seem very promising, it is important to note that the research around NMN is still in a relatively early phase.
The research indicates that NMN is generally safe and well tolerated in the doses that have been investigated and recommended. It is important to be aware that minor side effects may occur, just as with many other dietary supplements. These side effects are rare and usually mild, but it is still useful to be informed about them.
It is important to note that although many dietary supplements have a good safety profile based on existing research, individual response may vary due to this. This may be due to differences in metabolism, existing health conditions, interactions with other medications or supplements, and other factors.
The way forward
Summary
NMN is a breakthrough molecular compound with the potential to influence the aging process and promote good health by increasing NAD+ levels in the body. Through continued research and development, NMN can help shape the future of preventive health strategies and treatments.
References;
Shade C. The Science Behind NMN–A Stable, Reliable NAD+ Activator and Anti-Aging Molecule Integr Med (Encinitas). 2020;19(1):12-14. PMID: 32549859.
Rajman L, Chwalek K, Sinclair DA Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence: Cell Metabolism Cell Metab. 2018 Mar 6;27(3):529-547. doi: 10.1016/j.cmet.2018.02.011. PMID: 29514064
The Felicis J, Gans K NMN: Benefits, Side Effects And Dosage – Forbes Health
Yi L, Maier AB, Tao R, et al. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial - PMC Geroscience. 2023;45(1):29-43.