A new era of health
In recent years, NAD+ has gone from being an unknown coenzyme to becoming a central piece in the anti-aging and biohacking conversation. In 2025, we will see a sharp increase in searches for how to naturally increase NAD+ levels - both among older people seeking vitality and young people seeking optimal performance.
But what exactly is NAD+, why is everyone talking about it now - and does it work?
What is NAD+ and why is it important?
NAD+ (nicotinamide adenine dinucleotide) is found in all cells of the body and is essential for:
- Energy production (ATP)
- DNA repair
- Cell maintenance
In addition, NAD+ is essential for the activation of enzymes such as:
- Sirtuins : Regulate aging and DNA repair
- PARP enzymes : Repairs DNA damage
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CD38 : Affects the immune response
The problem is that NAD+ levels drop dramatically with age, often down to 50% by the age of 40. This contributes to what scientists refer to as a “cellular energy crisis.”
Scientific breakthrough and new interest
In the 2000s, researchers such as Leonard Guarente and Shin-ichiro Imai discovered that NAD+ is necessary for sirtuin activity - closely linked to aging and longevity.
Later, figures like David Sinclair and Andrew Huberman brought NAD+ into the spotlight as a key factor for energy, recovery, and anti-aging.
Studies have shown that supplements like NMN and NR can improve:
- Mitochondrial function
- Endurance
- Insulin sensitivity
- Cognitive performance
What is NMN - and why is it popular?
NMN (Nicotinamide Mononucleotide) is a direct precursor to NAD+ and is rapidly absorbed into the body. When consumed, NMN can be converted to NAD+ in just minutes, making it one of the most effective supplements for restoring NAD+ levels.
Advantages:
- Fast absorption and direct effect
- Good tolerance in studies (up to 1250 mg daily)
- Improved energy, mental clarity and metabolic health
What is NR - and why is it considered an alternative?
NR (nicotinamide riboside) is another precursor to NAD+ that the body converts to NMN before it becomes NAD+. It has been the subject of many human studies and is known for its broad systemic effects.
Advantages:
- Good documentation in clinical studies on humans
- Increases NAD⁺ levels in the blood by up to 2–3 times
- Supports overall cellular health and mitochondrial function
Although NR must be converted to NMN first, research shows that it is an effective and safe way to support the NAD+ cycle. Especially in combination with NMN, as it provides rapid and comprehensive NAD+ support.
Why are NMN and NR often combined with other substances?
To get the full effect of NAD+ boosting, the body needs support for detoxification and balance:
- TMG (Trimethylglycine) protects against methylation imbalance with high NMN intake
- Resveratrol and pterostilbene activate sirtuins and enhance the anti-aging effect
- Fisetin and quercetin help clear out old cells
- Spermidine activates autophagy - the cell's own “cleaning system”
This makes products like AgeX a complete formula with NR + supporting components for cell renewal and anti-aging.
Why will demand explode in 2025?
Several factors are driving the trend:
- Scientific interest : Several clinical studies and universities (including in Norway) are now researching NAD+, NR and NMN for, among other things, their effects on age-related diseases.
- Influencer-driven endorsements : Andrew Huberman, David Sinclair and Tim Ferriss give NAD+ legitimacy in popular media.
- Celebrities swear by it : Several famous profiles such as Hailey Bieber, Kendall Jenner and other profiles have shared their experiences with NAD+, which often involves increased energy, skin health and recovery.
- Health-conscious consumers : Increased focus on biohacking, fasting, and ketogenic diets - all known to increase NAD+.
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Better availability : Products like NMN and NR are now readily available in Norway.
Conclusion: A paradigm shift in health
Interest in NAD+ is exploding because the research supports it, the user experience confirms it, and the availability has never been better. It's no longer about extending life at all costs - but about maximizing function and vitality for as long as possible.
As more people take their health into their own hands, NAD+ and NMN mark the beginning of a new era where aging is not only accepted - but actively addressed.
If the article caught your interest, we recommend that you read the more in-depth version, which you can find by clicking here .
